Although the recent publications by Nerrant et al. and Brickshawana et al. [20, 21] reduce the novelty of our negative findings somewhat, our study was able to address important mechanistic questions related to the associations of KIR4.1 antibodies to MS genetic and environmental risk factors and to MS disease progression in a much larger study sample. This evidence concerns the gene KCNJ10 and myeloid sarcoma.