However, in agreement with our cumulative meta-analysis and previous standard meta-analyses, inclusion of patients using psychotropic medication and the lack of adjustment for overweight/obesity resulted in slightly larger effect size estimates between the levels of CRP, IL-6 and depression (Hiles et al., 2012b; Howren et al., 2009). This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.