However, Cav-1 was clearly up-regulated in subcutaneous xenograft tumor tissue derived from MIAPaCa-2 cells, patient-derived xenografts, and tumors from a well-characterized mouse model of pancreatic cancer bearing p53 (p53LSL-R270H) and KRAS (KRASLSL-G12D) mutations expressed in pancreatic epithelium with the Pdx1-cre transgene (“KPC mouse”) (Fig. 1B). This evidence concerns the gene PDX1 and familial pancreatic carcinoma.