Since JAK2, SOCS, JNK/SAPK, and Src signaling all converge and impinge on STAT3 signaling, our data suggests that loss of Cav-1 serves to reduce pancreatic cancer oncogenic proliferation, migration, invasion, and cell survival through a STAT3 mechanism (Fig. 7C). This evidence concerns the gene JAK2 and familial pancreatic carcinoma.