ITGAM and acute myeloid leukemia: Patterns of regulation of CD11b+ expression by these two drugs were very similar in NB4, Kasumi-1, and THP-1 AML cells, however their modulatory effects were opposite in HL60 cells: CD11b+ expression was decreased by radotinib in ATRA-treated HL60 cells, whereas it was increased by dasatinib (Fig 2A–2D).