GRIN2B and Pain: ● In rodent models of peripheral neuropathic pain, upregulated BDNF induced phosphorylation of the NR2B subunit of the NMDA receptor [50] that was accompanied by downregulation of Kv channels [45] as well as expression levels of KCC2 in lamina-I of the spinal cord, thereby disrupting GABAergic inhibition [51]