BDNF and myeloid sarcoma: In recent work from our laboratory that used our novel optimised relapsing-remitting EAE (RR-EAE) mouse model of MS-neuropathic pain [123], mature BDNF was found to be down-regulated whereas its precursor, pro-BDNF, was upregulated in the lumbar spinal cord of RR-EAE mice exhibiting pain behaviour [47].