● In rodent models of peripheral neuropathic pain, upregulated BDNF induced phosphorylation of the NR2B subunit of the NMDA receptor [50] that was accompanied by downregulation of Kv channels [45] as well as expression levels of KCC2 in lamina-I of the spinal cord, thereby disrupting GABAergic inhibition [51]. Here, SLC12A5 is linked to Pain.