In their study, Otomo et al. used the combination of the results of 5 clotting assays and 6 ELISA tests for the detection of antibodies against CL, B2GP1, and phosphatidylserine-dependent antiprothrombin (aPS/PT) of IgM and IgG isotypes to calculate an APS score for thrombosis [19]. This evidence concerns the gene CD40LG and autoimmune polyendocrinopathy.