When studying a group of APS patients and a group of healthy blood donors, Hoxha et al. found an increase of the specificity of the biological diagnosis to 100% when they analyzed the simultaneous positivity of aCL, anti-B2GP1, anti-FII, and LA, but with a decreased sensitivity (14.6%), this analysis comprises the IgM and IgG isotypes [10]. The gene discussed is CD40LG; the disease is autoimmune polyendocrinopathy.