In another study, Abós et al. [45] showed upregulation of MHC-II genes that coincided with upregulation of CD80/CD86 genes in a nonlethal infection (no cytopathic effects observed) of viral hemorrhagic septicemia virus (VHSV) in IgM+ cells which consolidates the notion that fish B-cells use CD80/CD86 molecules to activate the adaptive immune system using the MHC-II pathway [44, 46]. This evidence concerns the gene CD86 and infection.