When cancer cells reach the bone microenvironment, they induce the release of different factors enmeshed in the bone matrix, such as bone morphogenetic proteins (BMPs), transforming growth factor-β (TGF-β), insulin-like growth factor (IGF), and fibroblast growth factor (FGF) as well as others that stimulate the growth of metastatic tumor cells (Figure 1) [29]. This evidence concerns the gene TGFB1 and neoplasm.