INS and Insulin resistance: Our results showed that n-STZ-treated animals did not respond to insulin (Figure 1(c)) as observed by the significant increase of AUCITT (by 30%) in n-STZ-treated animals (10570 ± 1054 a.u.), when compared with rats from the control group (7420 ± 657 a.u.)(Figure 1(d)), illustrating that these rats developed insulin resistance.