No studies to date have examined in a single population a large number of polymorphisms (TNF-α  -308G/A, IL-10 -1082G/A, IL-10 -819T/C, IL-10 -592C/A, TGF-β1 codon 10T/C, TGF-β1 codon 25C/G, IL-6  -174G/C, and IFN-γ +874T/A) and their association with the T2D complications and comorbidities. This evidence concerns the gene TNF and type 2 diabetes mellitus.