PDGFRB and head and neck squamous cell carcinoma: Among the other two hub genes both with high degree of 16, EGFR has been among the most important prognostic factors for HNSCC [16], while the kinase PDGFRB was found to be up regulated in tumor indicating the effectiveness of tyrosine and serine-threonine kinase inhibitors in the treatment of HNSCCs [22].