In a miRNA profiling analysis in metastatic colorectal cancer (mCRC) patients treated with anti-EGFR monoclonal antibodies conducted by Cappuzzo et al. using 183 mCRC cases, the authors identified miRNA cluster let-7c/miR-99a/miR-125b as a signature associated with an outcome different from that of anti-EGFR therapies, and this miRNA cluster may be used for the selection of patients with KRAS wild-type mCRC as good candidates for anti-EGFR therapy [49]. Here, EGFR is linked to metastatic colorectal cancer.