For instances, miR-143, miR-21, and miR-155 could regulate the expression of NF-κB, an important transcription factor which involved in EGFR signaling pathway, sequentially enhance tumor apoptosis after exposure to 5-FU [74]; and the miR-181b and let-7g also have been widely involved in chemoresponse to S-1, a 5-FU-based antimetabolite [75]. The gene discussed is EGFR; the disease is neoplasm.