miR-328 was significantly reduced in CRC SP cells relative to the non-SP cells; functional studies using a gain-loss approach further demonstrated that the abundance of miR-328 could affect the frequency of SP cells in CRC, and ectopic expression of miR-328 could reverse drug resistance and inhibit cell invasion of SP cells; mechanistically, miR-328 was able to directly target ATP-binding cassette subfamily G2 (ABCG2) and matrix metallopeptidase 16 (MMP16) [78]. The gene discussed is MMP16; the disease is colorectal carcinoma.