For examples, miR-221 and miR-222, whose expressions are related to the TNM stage and local invasion of cancer and are frequently elevated in colon cancer, were able to inhibit angiogenic activities in HUVEC (human umbilical vein endothelial cells) by directly targeting angiogenic genes of c-Kit (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), Stat5A (signal transducer and activator of transcription 5A), ENOS (endothelial nitric oxide synthase), and ETS1 (v-ets erythroblastosis virus E26 oncogene homolog 1) [12]. The gene discussed is NOS3; the disease is cancer.