In the pathogenesis of metastatic CRC, abundant miR-200c could be detected in liver metastasis tissues, and overexpression of miR-200c in colon cancer cell lines led to a reduced expression of its target genes ZEB1, ETS1 and FLT1, and EMT markers (E-cadherin and vimentin) [8]. The gene discussed is ZEB1; the disease is colorectal carcinoma.