FLT1 and malignant colon neoplasm: For example, Hur et al. found that miR-200c was aberrantly expressed in metastatic colon tumor tissues and colon cancer cells, and this upregulated miR-200c was correlated with an reduction of the expression of its target genes: zinc finger E-box binding homeobox 1 (ZEB1), ETS1, and FMS-related tyrosine kinase 1 (FLT1), which in turn upregulates E-cadherin and downregulate the expression of vimentin, sequentially led an activation of EMT signaling pathway (Figure 1) [8, 55].