In a transgenic zebrafish model of AML, MYCN, under the control of a CMV minimal promoter and a MOZ/TIF2 fusion gene generated by the inv(8)(p11q13) chromosomal abnormality expressed under the spi1 promoter, resulted in altered hematopoiesis and was characterized by invasion of the kidney marrow by immature myeloid cells [58, 70]. This evidence concerns the gene MYCN and acute myeloid leukemia.