RUNX1 and acute myeloid leukemia: RAS mutations associated with cancer frequently occur in patients with AML, suggesting a functional role for Ras in leukemogenesis. AML1/ETO rearrangements are detected frequently in AML, especially M2, and are associated with a relatively good prognosis [49]. K-RASG12D interacts with AML1/ETO to induce acute monoblastic leukemia in a mouse model [50].