It has recently been reported that echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) gene fusions are present in approximately 3% of patients with NSCLC and that EML4 and ALK amplifications may play a role in NSCLC transformation [9]. The gene discussed is EML4; the disease is non-small cell lung carcinoma.