Despite of that, association of LEP G-2548A and LEPR Gln223Arg polymorphisms with obesity and leptin serum levels in other populations has been studied with controversial results [18, 43, 44], and the relationship between leptin and leptin-receptor polymorphisms with the serum levels of both molecules (sLeptin and sLeptin-receptor) and adiposity has not been explored. Here, LEPR is linked to obesity due to melanocortin 4 receptor deficiency.