A mouse model with mutations in both CYP1B1 and Tyr was also developed and revealed that Tyr mutation modifies the phenotype associated with inheritance of mutant orthologs of CYP1B1 and Foxc1, both of which have been shown to be involved in human angle-closure glaucoma [96, 97]. The gene discussed is CYP1B1; the disease is angle-closure glaucoma.