BRAF and cardiofaciocutaneous syndrome: Mutations causing these syndromes lead to activation of the RAS-MAPK pathway. BRAF haploinsufficiency is not expected to be a causative mechanism of CFC; however it is interesting to note that our patient's course facial features overlap with many course facial features of CFC, including bulbous nasal tip and depressed nasal bridge, hypertelorism, downslanting palpebral fissures, and prominent philtrum.