Soluble CD40 ligand levels were higher in OSA compared with controls (15,128 ± 597 pg/mL versus 5729 ± 653 pg/mL, P < 0.00001) and were reduced after treatment (adenotonsillectomy) (9866 ± 702 pg/mL, P < 0.0002) [115]. This evidence concerns the gene CD40LG and obstructive sleep apnea syndrome.