LDHC and male infertility: Sperm bioenergetics is a topic of significant interest due to the potential implications for fertility of impairment of metabolism, for example, Odet et al. [33] showed how lactate dehydrogenase C is involved in both glycolysis and ATP homeostasis, and its disruption leads to loss of progressive and hyperactivated motility and male infertility in mice; Piomboni et al. [34] recently reviewed data on mitochondrial defects associated with asthenozoospermia and argued for further investigation into mitochondrial energy metabolism owing to its relevance to physiological and pathological function.