TRPV4 and Sepsis: Numerous endogenous agonists and regulators of TRPV4, including anandamide (Vargaet al., 1998), arachidonic acid and its metabolites (Bruegelet al., 2012), protein kinase A (Yanget al., 1997), shear stress and temperature have been shown to be upregulated or altered in sepsis.