TRPV4 and Sepsis: Nonetheless, plasma levels of the compound have been shown to remain above the IC50 for more than 2 h after intraperitoneal administration of 10 mg/kg HC-067047 (Everaertset al., 2010), suggesting that any prominent role for TRPV4 in sepsis-associated cardiovascular dysfunction would at least have been evident in the early phase of sepsis.