Because IL-22R1 can combine not only with IL-10R2 to act as a functional IL-22R complex but can also interact with IL-20R2 to form a receptor for IL-20 and IL-24 [32], it is likely that IL-22R1 ligands other than IL-22 may play a role in ameliorating HFD-induced metabolic syndrome. The gene discussed is IL22RA1; the disease is metabolic syndrome.