REST and Alzheimer disease: Since REST is a protective factor in the ageing brain, which is in a state of decline from the early stages of AD [40], and because we have recently found that RNSP taken orally for 16 weeks can significantly improve cognitive function in the early stages of AD [18], the regulation of the H2O2-mediated REST/oxidative stress may be one of the principle molecular mechanisms behind the protective effects of RNSP that are observed in neuronal cells.