Shen et al. have found that in Alzheimer disease (AD) neuronal cells expressing ABCG2 are able to (i) protect cells from ROS-induced toxicity/death; (ii) inhibit ROS-induced expression of inflammatory genes (IL-8 and GRO) and decrease ROS-induced IL-8 cytokine secretion; (iii) inhibit ROS-induced phosphorylation of IκB and activation of NF-κB; (iv) inhibit the uptake of hemin chloride and decrease ROS generation into the cells [103]. The gene discussed is CXCL8; the disease is early-onset autosomal dominant Alzheimer disease.