Lin et al. have recently shown that targeting the antioxidant protein peroxiredoxin 4 (PRDX4) can amplify cell death through ROS-mediated DNA/endoplasmic reticulum damage, raising the possibility that PRDX4 may be a novel therapeutic target in glioblastoma multiforme to inhibit glioma stem cell survival and/or growth [35]. The gene discussed is PRDX4; the disease is glioma.