Recently, it has been reported that the miR-146a expression is absent in pancreatic cancer cells while reexpression of miR-146a results in lower capacity of tumor cell invasion, consistent with inactivation of EGFR and NF-κB pathways, leading to the downregulation of NF-κB target genes [143]. The gene discussed is NFKB1; the disease is familial pancreatic carcinoma.