CASP3 and Alzheimer disease: Moreover, the mitochondrial division inhibitor 1 (mdivi-1) attenuated the degree of apoptosis in an Aβ-induced model of AD in BV-2 and primary microglial cells, then counteracting another pathological feature of AD, such as neuroinflammation; this effect is probably mediated through its effects on mitochondria, since Mdivi-1 reversed abnormal mitochondrial fission, MMP loss, CytC release, and caspase-3 activation [223].