TM6SF2 and Cirrhosis: Another single nucleotide polymorphism which has been recently correlated with the development and prognosis of NAFLD is a glutamate to lysine amino acid substitution at residue 167 in transmembrane 6 superfamily member 2 (TM6SF2) sequence; the T allele of this gene is associated with the development of NAFLD, its progression to fibrosis and cirrhosis, and also altered cholesterol metabolism [91]; however there are some contradictions in literature and further studies are required to validate its role in larger cohorts of patients [92].