GLA and Sepsis: According to our search of the PubMatrix database (http://pubmatrix.grc.nia.nih.gov/), 9 out of the 15 upregulated genes in the lysosome pathway (including GLA, CD63, GNS, and LAMP2) and 7 in the cytoskeleton pathway (including CD14, integrins, and MAPK1) have been reported in the literature associated with search terms “sepsis,” “severe sepsis,” or “septic shock” (Table 3).