According to our search of the PubMatrix database (http://pubmatrix.grc.nia.nih.gov/), 9 out of the 15 upregulated genes in the lysosome pathway (including GLA, CD63, GNS, and LAMP2) and 7 in the cytoskeleton pathway (including CD14, integrins, and MAPK1) have been reported in the literature associated with search terms “sepsis,” “severe sepsis,” or “septic shock” (Table 3). The gene discussed is CD63; the disease is Sepsis.