According to rank scores and frequency of appearance, we found robust upregulation of multiple KEGG pathways in whole blood samples of human sepsis across all studies examined, including “Lysosome,” “Regulation of actin cytoskeleton,” “Pathways in cancer,” “MAPKinase signaling,” “Fc gamma R-mediated phagocytosis,” “Chemokine signaling pathway,” “Toll-like receptor signaling,” “Neurotrophin signaling pathway,” “Insulin signaling pathway,” and “Focal adhesion” (Figure 2 and Table 2). This evidence concerns the gene BDNF and Sepsis.