Thus, Pg and its virulent factors as well as high-fat diet-induced high-concentration LDL stimulation can induce systemic inflammatory response that activates the NF-κB pathway in artery endothelial cells and subendothelial inflammatory cells, which further increases inflammatory factors and leads to a vicious circle as the pathogenesis of Pg-induced atherosclerosis. The gene discussed is NFKB1; the disease is atherosclerosis.