MMP9 and soft tissue sarcoma: Sachdeva et al. [37] identified miR-182 as an overexpressed miRNA in a subset of soft tissue sarcomas that metastasized to the lungs in a mouse model and demonstrated that miR-182 was a driver of tumor metastasis in vivo by enhancing the activation of extracellular proteases, including urokinase and MMP-9, and repressing multiple proteins that prevent tumor cell intravasation.