INS and Insulin resistance: Insulin resistance can result in hyperadiponectinaemia and adiponectin resistance in insulin receptor transgenic/knockout mice [35], in adipocyte-specific insulin receptor (Insr) knockout mice [36] or in mice with muscle-specific insulin resistance due to transdominant inhibition of Insr and IGF-1 receptors [37], suggesting that adiponectin production is controlled in response to changes in systemic insulin sensitivity.