Multivariate regression analysis revealed that female gender, lower baseline body fat mass, not having hypertension, greater increases in glucose, and greater reductions in triglycerides and body fat mass during the study were associated with greater increases in adiponectin levels (Table 3) and these factors explained 31.3% of variance in the adiponectin change in response to niacin/laropiprant. The gene discussed is ADIPOQ; the disease is Hypertension.