In the present study, there was no significant difference in the baseline adiponectin concentrations in patients with and without hypertension, and this may be related to the antihypertensive treatments received in patients with hypertension as some antihypertensive drugs, for example, angiotensin II type 1 receptor blockers (ARBs), are known to increase plasma adiponectin concentrations, probably through PPAR-γ activation [40, 42]. This evidence concerns the gene ADIPOQ and hypertensive disorder.