Interestingly, Piccio L et al.36 have revealed that AD deficient mice could develop worse experimental autoimmune encephalomyelitis (EAE) with greater central nervus system (CNS) inflammation, more lymphocytes proliferation, higher amounts of interferon-γ (IFN-γ), IL-17, TNF-α and IL-6 than wild type (WT) mice. The gene discussed is TNF; the disease is experimental autoimmune encephalomyelitis.