In this study, we demonstrated in two human ovarian cancer cells lines, one highly chemoresistant, that LA suppressed the proliferation and induced the cell death in both cell lines by decreasing of Mcl-1 and Bcl-xL expression, two anti-apoptotic proteins; whereas the induction of CHOP could promote Bim transcription. The gene discussed is DDIT3; the disease is ovarian carcinoma.