Total TAGs were significantly elevated in impaired animals (OR, 31.37; P = 0.0006) at time of diagnosis (Fig. 2), and this in combination with insulin sensitivity data (Table 1) and biometric data (Fig. 1) satisfies established rhesus monkey criteria for metabolic syndrome (10): insulin resistance, plasma TAG >80 mg/dl, and adiposity in excess of 25%. The gene discussed is INS; the disease is metabolic syndrome.