Among the CNS-related genes, the highest measures of genetic effects on CFS prediction were provided by SNPs in HSD11B1 (rs846906), HTR2A (rs1923884), MAOB (rs1799836), CRHR1 (rs1396862), SLC18A2 (rs363236), NOS3 (rs891512), and DRD2 (rs1124492). Here, CRHR1 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.