In our current cohort of IBD patients with IND, 27% of cases had ≥ 5% epithelial nuclei with intense p53 expression; this rate is comparable with the results of a previous study that found 21% of colon biopsies with IND showed intense nuclear p53 immunoreactivity in ≥ 5% epithelial nuclei [19]. This evidence concerns the gene TP53 and inflammatory bowel disease.