Our results indicate that the overexpression of p53—as analysed by Immunohistochemistry—predicts colorectal neoplasia progression in IBD patients with IND; this finding is consistent with previous studies that found p53 overexpression (defined as intense nuclear immunoreactivity) was a risk factor for colorectal neoplasia progression in UC and CD [20–22]. This evidence concerns the gene TP53 and inflammatory bowel disease.