PSEN1 and early-onset autosomal dominant Alzheimer disease: This hypothesis may have impact on the translation of therapeutic efforts from these familiar forms of Alzheimer’s disease, which are currently used to study the treatment of very early stages of Alzheimer’s disease like the Alzheimer’s Prevention Initiative enrolling members of a Columbian cohort who carry the E280A PS1 mutation, to the treatment of sporadic Alzheimer’s disease.