In accordance with the results of a previous study (54), the present study indicated that the total glycosides of rhodiola can suppress TIPE2 expression in mice with sepsis, lower the expression of the apoptosis-promoting proteins Fas and FasL, decrease T-lymphocyte apoptosis, increase the number of thymus T lymphocytes and the CD3+, CD4+ and CD4+/CD8+ T-lymphocyte sub-sets, increase the levels of Th1 cytokines, including IFNγ, IL-2 and IL-12, and enhance the host’s immunity. This evidence concerns the gene CD4 and Sepsis.