In systemic lupus erythematosus, 11 key genes were differentially expressed between carcinoma, para-carcinoma and relapse tissue, including: HLA-DPB1, HIST1H4J, HIST1H2BO, H3F3C, H2AFY, H3F3A, HIST2H3D, HIST1H4D, HIST2H4B, HIST1H2BL and HIST1H4K (Fig. 2, Table V). Here, H3-5 is linked to carcinoma.