Serum HMGB1 levels were significantly higher in GCA patients than in TA patients, and even though the ROC analysis showed that a cutoff value of 2.17 ng/ml in HMGB1 levels would help to differentiate GCA from TA, we believe that it is unlikely that in clinical practice it would replace the 50-year-old cutoff point used to differentiate both entities [1]. This evidence concerns the gene HMGB1 and temporal arteritis.