Numerous cytokines, such as IL-1α, IL-4, IL-6, IL-8, IL-10, IL-16, TNF-α, CCL2, and CXCL10 were identified in the orbital tissue and serum from patients with GO and are, therefore, proposed to play a significant role in GO pathogenesis [7–10]. This evidence concerns the gene IL1A and geroderma osteodysplastica.