The aims of this study were as follows: (1) to evaluate the serum concentration of HGF and IL-8 in the blood of newly diagnosed Graves’ disease patients with the first episode of active GO and healthy controls; (2) to estimate the influence of the thyroid function (euthyreosis vs. hyperthyreosis) on HGF and IL-8 blood levels in patients with active GO; (3) to evaluate the influence of intravenous methylprednisolone (MP) pulse therapy and additional oral MP therapy on HGF and IL-8 blood levels in patients with active GO. Here, HGF is linked to thyroid gland disorder.