In one study, however, improved mean BMI (32.4 vs. 41.2), body composition, lower mean hemoglobin A1c, lower mean insulin resistance, and less hypertension were reported in 20 adults (mean age 25.4 years) with PWS at 7.0 ± 4.4 years after discontinuing treatment initiated at age 11.8 ± 2.7 years when compared with 40 untreated PWS adult group [86]. Here, INS is linked to Prader-Willi syndrome.