We focused on the 37LRP-derived “peptide G” sequence (residues 161–180, IPCNNKGAHSVGLMWWMLAR) that binds LM with high affinity (Kd = 51.8 nM) [11, 15, 17], elutes 67LR from LM affinity chromatography columns [17], and mediates many functional effect linked to tumor progression, such as increased cell adhesion and migration to exposed ECM [18], increased tumor cell adhesion to endothelial cells and metastasis formation [15] and release of motility fragments from LM [19]. The gene discussed is RPSA; the disease is neoplasm.