Accordingly with the cooperative effects exerted by MYCN and LSD1 in keeping the repressive state of these two growth suppressor genes, we found that combined pharmacological inhibition of MYCN and LSD1 through the use of small molecule inhibitors of MYCN and LSD1 (TCP and 10058-F4) synergistically reduces Neuroblastoma cell viability in vitro through activation of the apoptotic process. Here, MYCN is linked to neuroblastoma.