Moreover, several recent reports highlight the crucial role for LSD1 in inhibition of differentiation genes; recently the ubiquitin-proteasome E3 ubiquitin ligase, Jade-2 was identified as a major LSD1 negative regulator during neurogenesis that specifically targets LSD1 for degradation and promotes Neuroblastoma cell differentiation [33]. Here, KDM1A is linked to neuroblastoma.