We then investigated the inhibitory effect of these miRNAs on LDHA in human colorectal caner and pancreatic cancer cell lines, and found that cells stably expressed miR-34a, miR-34c, miR-369-3p, miR-374a and miR-4524a/b decreased the protein level of LDHA in varying degrees (Figure 4G). The gene discussed is LDHA; the disease is familial pancreatic carcinoma.