CCL2 and neoplasm: CCL2/MCP-1, CCL5/RANTES and ELR+ CXC chemokines (ELR motif: glutamic acid-leucine-arginine) have shown pro-tumor activity by recruiting and inducing myeloid cells to differentiate into tumor-associated macrophages (TAM) that exert pro-growth activity inducing neoangiogenesis and inhibition of development of anti-tumor T-cell responses in situ.