ACKR1 and neoplasm: Additionally, two atypical chemokine receptors which are characterized by their inability to transduce conventional signalling, but are able to regulate immune responses by acting as chemokine decoy/scavengers or transporters, the Duffy antigen receptor for chemokines (DARC) and the chemokine scavenger receptor D6, have shown anti-tumoral activity associated with tumor necrosis, decreasing of CC chemokines and MMP9, promoting angiostasis by scavenging of CXC chemokines, and addressing senescence signalling to tumor principally through KAII/CD82 [108,109].