It has been reported that Fabp4 deficiency-induced LXRα up-regulation in macrophage resulted in an increase in the activity of stearoyl CoA desaturase-1 (SCD-1), an enzyme that converts endogenous saturated fatty acids (SFA) to monounsaturated fatty acids (MUFA), and thereby reduced ER stress and atherosclerosis [8]. This evidence concerns the gene NR1H3 and atherosclerosis.