We observed splenic lymphopenia in the EdnrBNCC-/- animals (EdnrBNCC+/- 2.6x107±0.19x107 vs. EdnrBNCC-/- 1.2x107±0.19x107, p = 0.002), as has previously been described in the conventional EdnrB mutants [47]. This evidence concerns the gene EDNRB and lymphopenia.