Hypoglycaemia is particularly prevalent amongst those on insulin (mild/moderate: prevalence = 52%, incidence = 23 events/ year; severe: prevalence = 21%, incidence = 1 event/year, yet still fairly common for treatment regimens that include sulphonylureas (mild/moderate: prevalence = 33%, incidence = 1.92 events/year; severe: prevalence = 5, incidence = 0.01 events/year. This evidence concerns the gene INS and Hypoglycemia.