The accurate differentiation of DLB and AD, however, is particularly important as:1) the aetiological basis of both diseases is likely to be different[2];2) DLBs exhibit adverse sensitivity to neuroleptics; and 3) DLBs have a differing prognosis compared to AD[3],but yet a better response to cholinesterase inhibitors[4]. Here, BCHE is linked to Alzheimer disease.