Aberrant RANKL/RANK signaling reprograms the salivary gland epithelium to an aggressive proliferative phenotype that leads to the emergence of multifocal palpable salivary gland tumors within a short latency period with histopathologic features consistent with a poorly differentiated mucoepidermoid cancer [26, 27]. The gene discussed is TNFRSF11A; the disease is tumor of salivary gland.