Further supporting an aggressive tumor phenotype, a number of molecular markers (i. e. slug/snail; vimentin; zinc finger E-box binding homeobox 1 (zeb1); and p63) associated with advanced stage malignancies and poor prognosis were significantly elevated in these tumors (Fig 3D–3O; and western analysis in S5 Fig)). This evidence concerns the gene SNAI1 and neoplasm.