Considering our current knowledge gap concerning the molecular mechanisms that underlie salivary gland tumorigenesis along with the increasing support for the RANKL/RANK signaling axis in the promotion of other head and neck cancers and inflammatory disorders [28–30], we believe our studies offer a new conceptual framework with which to gain further molecular insight into the etiopathogenesis of this understudied cancer which may lead to novel clinical avenues for diagnosis, prognosis, and/or treatment in the future. Here, TNFSF11 is linked to head and neck cancer.