In the current analysis, higher IL‐10 or IFN‐γ was only associated with asthma in the context of high IL‐5 and IL‐13 productions; children who produced IL‐10 but no IL‐5 (Class 1), or IFN‐γ but no IL‐5 (Class 2) were not at increased risk of asthma. This evidence concerns the gene IFNG and asthma.